National Institutes of Health (NIH) -funded study finds changes can affect food intake control circuitry and cause disorders to progress.
New Delhi, 02nd July 2021. Researchers have found that eating disorder behaviours, such as binge-eating, alter the brain’s reward response process and food intake control circuitry, which can reinforce these behaviours. Understanding how eating disorder behaviours and neurobiology interact can shed light on why these disorders often become chronic and could aid in the future development of treatments.
The study, published in JAMA Psychiatry, was supported by the National Institutes of Health.
National Institutes of Health (NIH) is the United states’ medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases
“This work is significant because it links biological and behavioural factors that interact to adversely impact eating behaviours,” said Janani Prabhakar, PhD, of the Division of Translational Research at the National Institute of Mental Health, part of NIH. “It deepens our knowledge about the underlying biological causes of behavioural symptom presentation related to eating disorders and will give researchers and clinicians better information about how, when, and with whom to intervene.”
Eating disorders : serious mental illnesses
Eating disorders are serious mental illnesses that can lead to severe complications, including death. Common eating disorders include anorexia nervosa, bulimia nervosa, and binge-eating disorder.
Behaviours associated with eating disorders can vary in type and severity and include actions such as binge-eating, purging, and restricting food intake.
In this study, researchers wanted to see how behaviours across the eating disorder spectrum affect reward response in the brain
In this study, Guido Frank, M.D., at the University of California San Diego, and colleagues wanted to see how behaviours across the eating disorder spectrum affect reward response in the brain, how changes in reward response alter food intake control circuitry, and if these changes reinforce eating disorder behaviours. The study enrolled 197 women with different eating disorders (including anorexia nervosa, bulimia nervosa, binge-eating disorder, and other specified feeding and eating disorders) and different body mass indexes (BMIs) associated with eating disorder behaviours, as well as 120 women without eating disorders.
The researchers used cross-sectional functional brain imaging to study brain responses during a taste reward task. During this task, participants received or were denied an unexpected, salient sweet stimulus (a taste of a sugar solution). The researchers analyzed a brain reward response known as “prediction error,” a dopamine-related signalling process that measures the degree of deviation from the expectation, or how surprised a person was receiving the unexpected stimulus. A higher prediction error indicates that the person was more surprised, while a lower prediction error indicates they were less surprised. They also investigated whether this brain response was associated with ventral-striatal-hypothalamic circuitry, a neural system associated with food intake control.
The researchers found that there was no significant correlation between BMI, eating disorder behaviour, and brain reward response in the group of women without eating disorders. In the group of women with eating disorders, higher BMI and binge-eating behaviours were associated with lower prediction error responses. Further, for the women with eating disorders, the direction of ventral striatal-hypothalamic connectivity was the reverse of those without eating disorders, with connectivity directed from the ventral striatum to the hypothalamus. This connectivity was positively related to the prediction error response and negatively related to feeling out of control after eating.
These results suggest that for the women with eating disorders, eating disorder behaviours and excessive weight loss or weight gain modulated the brain’s dopamine-related reward circuit response, altering brain circuitry associated with food intake control, and potentially reinforcing eating disorder behaviours.
For example, women with anorexia nervosa, restrictive food intake, and low BMIs had a high prediction error response. This response may strengthen their food intake-control circuitry, leading these women to be able to override hunger cues. In contrast, the opposite seems to be the case for women with binge-eating episodes and higher BMIs.
“The study provides a model for how behavioural traits promote eating problems and changes in BMI, and how eating disorder behaviours, anxiety, mood, and brain neurobiology interact to reinforce the vicious cycle of eating disorders, making recovery very difficult,” said Dr Frank.
Overall, this study suggests that behavioural traits, including food intake behaviour, contribute to eating disorder maintenance and progression by modulating one’s internal reward response and altering food intake control circuitry. However, further research is needed to investigate treatments that could target and change behaviours for individuals with eating disorders to achieve lasting recovery.
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