childhood cancer


Genetic clues, the potential for tailored therapy: a study of rare childhood cancer

New findings suggest that children with rhabdomyosarcoma could benefit from tumour genetic testing. Childhood Rhabdomyosarcoma Treatment In children with rhabdomyosarcoma, or RMS, a rare cancer that affects the muscles and other soft tissues, the presence of mutations in several genes, including TP53, MYOD1, and CDKN2A, appears to be associated with a more aggressive form of the disease and a poorer chance of survival. This finding is from the largest-ever international study on RMS, led by scientists at the National Cancer Institute’s (NCI) Center for Cancer Research, part of the National Institutes of Health. The study, published in the Journal of Clinical Oncology on June 24, provides an unprecedented look at data for a large cohort of patients with RMS, offering genetic clues that could lead to more widespread use of tumor genetic testing to predict how individual patients with this childhood cancer will respond to therapy, as well as to the development of targeted treatments for the disease. “These discoveries change what we do with these patients and trigger a lot of really important research into developing new therapies that target these mutations,” said Javed Khan, M.D., of NCI’s Genetics Branch, who led the study. “The standard therapy for RMS is almost a year of chemotherapy, radiation therapy, and surgery. These children get a lot of toxic treatments,” said the study’s first author, Jack Shern, M.D., of NCI’s Pediatric Oncology Branch. “If we could predict who’s going to do well and who’s not, then we can really start to tailor our therapies or eliminate therapies that aren’t going to be effective in a particular patient. And for the children that aren’t going to do well, this allows us to think about new ways to treat them.” What is rhabdomyosarcoma (RMS) RMS is the most common type of soft tissue sarcoma in children. In patients whose cancer has remained localized, meaning that it has not spread, combination chemotherapies have led to a five-year survival rate of 70%-80%. But in patients whose cancer has spread or come back after treatment, the five-year survival rate remains poor at less than 30%, even with…

Hope B’LIT wit founder Ruhi Hak

NGO Is For Passion, Not Livelihood Says Ruhi Hak

By news Help Line  Hope B’LIT founder Ruhi Hak who is achieving unprecedented landmark with her prolific work in Cancer care, says that NGO is for passion, do not make it your job. CANKIDS India collaborated with Los Angeles Based NGO HOPE B’Lit Team to come together to support and spread joy in the life of those who have been affected by Cancer. On 21st December, 2019 at CanKids…KidsCan, New Delhi, survivors and Cancer patients got together with supporters to felicitate and provide financial aid to Cancer Patients. The Chief Guests at the event were Ruhi Hak (Founder- Hope B~LIT), Sonal Sharma (Co-founder, CanKids), Poonam Bagai (Founder, CanKids), Harsh Kumar (COO, CanKids) Model Ashley Obregon, and media partners Ezilon Media Pvt Ltd were at the event. Talking about making head ways with her NGO, Ruhi Hak said, “I am a networking engineer, that is my regular job, but Hope B’lit is my life’s purpose. It’s passion for me, which my friends helped me realize and achieve. And I would like give out this message only, NGO is not a regular job, if you don’t make it as regular job, it would be beneficial for the NGO. Earn your bread from someplace else, because then you wouldn’t have to worry about your survival. Have a second source for living and whatever you make or earn in NGO, give it to your cause. The structure of NGO’s have gone for a toss because people end up making it their job, don’t do it. NGO is a passion and let it be your passion” CanKids…KidsCan is a National Society for Change for Childhood Cancer in India for holistic care for children with cancer and their families since 2004. It aims to improve Survival of children with cancer, Quality of Life and the Rights of the Child with Cancer and the Family. Talking about the negativity Ruhi faced and how she made it her stepping stone of success, she added, “In India it is different, but when I went to USA, they asked me for my qualifications and I faced a lot of negativity,…