Single-shot COVID-19 vaccine produces an immune response against variants
The immune response to the single-shot Janssen/Johnson & Johnson COVID-19 vaccine remained robust against variants of SARS-CoV-2. Although the vaccine produced fewer neutralizing antibodies against the variants than the original virus, the overall immune response suggests strong protection. —by Sharon Reynolds (NIH ) To date (June 29, 2021), three vaccines against SARS-CoV-2—the virus that causes COVID-19—have received emergency authorization for use in the U.S. All showed excellent protection against severe or critical disease in the clinical trials that led to their approval. However, these vaccines were developed early in the pandemic, before the virus mutated to produce the variants now found around the world. Some variants seem to be able to partially escape the immune response in people previously infected with the virus. you might want to read this too – Learn, Who should or shouldn’t take the COVID-19 vaccine Scientists haven’t been sure if the current COVID-19 vaccines work as well against these variants. Early data for these vaccines have been promising. For example, the clinical trial testing the Ad26.COV2.S vaccine, by Janssen/Johnson & Johnson, showed that it protected people in Brazil and South Africa during times when new variants dominated. you might want to read this too – COVAX expects to start sending millions of COVID-19 vaccines to Africa in February Researchers led by Dr Dan Barouch from Beth Israel Deaconess Medical Center wanted to examine the immune response to SARS-Cov-2 variants after vaccination with Ad26.COV2.S. The team looked at blood samples from 20 volunteers. Participants had received either Ad26.COV2.S at various doses and schedules or a placebo vaccine. The researchers tested antibodies and immune cells from samples taken 57 days after vaccination. They tested activity against the original strain of SARS-Cov-2 as well as several variants. These included the alpha, beta, and gamma variants, and another first isolated in California. you might want to read this too – An effective COVID-19 vaccine: Will you take it or will you not? The study was funded in part by NIH’s National Institute of Allergy and Infectious Diseases (NIAID). Results were published on June 9, 2021, in Nature. As expected,…