persistence

Innate lymphoid cells (green) near and within a small area of inflammation, or granuloma, in a non-human primate infected with Mycobacterium tuberculosis, the bacteria that cause tuberculosis (TB)

NII to host global symposium on extra-pulmonary Tuberculosis. India accounts for 27% of the world’s TB burden

New Delhi, February 03 : The Department of Biotechnology’s autonomous institute, the National Institute of Immunology (NII) along with International Centre for Genetic Engineering & Biotechnology (ICGEB), New Delhi is organizing a specialized symposia on extra-pulmonary tuberculosis from February 11 to 15. During the meeting, discussion and deliberation will be held on thematic areas like phenotypic heterogeneity and persistence, mycobacterial lifestyle, metabolism, and signaling in the host microenvironment, host immunity, alternate niches of mycobacteria, systems biology of mycobacterial pathogenesis, drug resistance in tuberculosis, and extra-pulmonary TB. Tuberculosis (TB) continues to be a major global health problem. India accounts for 27% of the world’s TB burden. Over past few years, the country has experienced some slowdown in pulmonary TB cases. However, the number of extra-pulmonary cases is on the increase. This has added to the overall burden of the TB in India and has become a cause of alarm. At present, no definitive diagnostics are available for detecting extra-pulmonary TB, and the available treatments regimes are of long durations. Extra-pulmonary TB patients are given broad spectrum and mycobacterial-specific antibiotics primarily meant for pulmonary TB but for longer durations of 12-24 month. Long duration treatment regimes affect the patient compliance. According to multiple clinical reports, such treatment regimes have resulted in the prevalence of multi-drug resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis. In line with this, India contributes to 25% of the global MDR-TB burden. Among other things, there are concerns that long treatments could create drug resistant gene reservoir in the intestinal microbiome of extra-pulmonary TB patients. Some studies have shown a close link between persistent gut microbial alterations (dysbiosis), immune system and TB treatment. The ensuing symposium will also address the global emerging threat associated with phenotypic and genotypic diversity of pathogen M. tuberculosis and its consequences on disease development, host-response and drug resistance. The host-pathogen cross talk or interaction is a key factor responsible for M. tuberculosis infections. During the past two decades, pulmonary TB have been studied in depth and several important characteristic features of M. tuberculosis replication, intracellular survival, lipid and carbon metabolism,…