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WHO recommended two new drugs to treat COVID-19

The drugs add to an expanding toolbox for COVID-19 treatment

COVID-19 Treatment Guidelines: In its latest COVID guidelines, WHO ‘strongly recommends’ the Baricitinib antibody treatment for critical patients.

New Delhi/ Geneva 14 January 2021 | The world Health Organization (WHO) has recommended two new drugs for COVID-19, providing yet more options for treating the disease.  The extent to which these medicines will save lives depends on how widely available and affordable they will be.

WHO ‘Strongly’ Recommends Baricitinib for COVID-19 Patients: What Is It?

The first drug, baricitinib, is strongly recommended for patients with severe or critical COVID-19.  It is part of a class of drugs called Janus kinase (JAK) inhibitors that suppress the overstimulation of the immune system.  WHO recommends that it is given with corticosteroids.

Baricitinib dose for COVID

Baricitinib is an oral drug, used in the treatment of rheumatoid arthritis.  It provides an alternative to other arthritis drugs called Interleukin-6 receptor blockers, recommended by WHO in July 2021.

Sotrovimab covid treatment

WHO has also conditionally recommended the use of a monoclonal antibody drug, sotrovimab, for treating mild or moderate COVID-19 in patients who are at high risk of hospitalization. This includes patients who are older, immunocompromised, having underlying conditions like diabetes, hypertension, and obesity, and those unvaccinated.

Sotrovimab: What to Know About the WHO Recommended COVID Treatment
WHO has also clarified that it is not certain about Sotrovimab’s effect on Omicron variant infected COVID patients.

Sotrovimab is an alternative to casirivimab-imdevimab, a monoclonal antibody cocktail recommended by WHO in September 2021. WHO has also clarified that studies are ongoing on the effectiveness of monoclonal antibodies against Omicron but early laboratory studies show that sotrovimab retains its activity.

The panel of experts developing the guidelines also looked at two other drugs for severe and critical COVID-19: ruxolitinib and tofacitinib.  Given their uncertain effects, WHO made a conditional recommendation against their use.

According to WHO, the two newly recommended drugs – baricitinib and sotrovimab – have been invited for WHO Prequalification, which assesses the quality, efficacy and safety of priority health products to increase access in lower income countries.

According to WHO these recommendations, forming the eighth update of WHO’s living guidelines on therapeutics and COVID-19, are based on evidence from seven trials involving over 4,000 patients with non-severe, severe, and critical COVID-19.

WHO is in discussions with manufacturers to secure global supply capacity and equitable and sustainable access to the newly recommended therapeutics.  The Access to COVID-19 Tools Accelerator (ACT-A) Therapeutics pillar has been engaging with pharmaceutical companies to seek comprehensive access plans for low- and middle-income countries, so that these treatments can be rapidly deployed everywhere, not just in rich countries.  The ACT-A is also looking to expand licensing scope to make the products more affordable.

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