New
Delhi, December 26 : Diabetes cannot be cured but it can be managed. Its
management becomes difficult when a patient has to monitor it every day through
piercing his or her finger to check the blood sugar level. Now an international
team of researchers hasself-powered glucose biosensor technology base device that can
measure the blood sugar level through saliva samples also. This device can work
inside the body without using any external electrical energy.
By Jyoti Singh
Continuous monitoring of fluctuating sugar level
in blood is often required for patients with diabetes. Implantable
glucose biosensors could mitigate the painful finger-pricking process. However,
the electricity requirement for the implantable glucose-sensing devices is the
major challenge, making the implantation a complicated process.
“The team has demonstrated
a linear response to glucose at concentrations relevant for non-diabetic and
diabetic saliva. The sensor will be useful for the quick, accurate
and early detection of abnormalities in metabolism that helps monitor, control and prevent many metabolic disorders, including diabetes” said Dr P. Tamilarasan, Scientist
and research team member, Council of Scientific and Industrial Research –
Central Electrochemical Research Institute (CSIR-CERI).
Any implantable electrical
or electrochemical device requires electrical energy for its operation.
Producing electricity inside the human body is a challenging task. This
complete device can function inside the body without external electricity
supply. In this technology, an electron-transporting n-type
semiconductor polymer and an enzyme are used to extracts electrons proportional to glucose level in bodily fluid. The polymer based electrode
that can be used for glucose sensing as well as electricity generation. On the
other hand, an enzymatic fuel cell using same materials has been developed to
generate electricity using the glucose in bodily fluids. Glucose is sensed by a
transistor made up of the polymer which is powered by the enzymatic fuel cell
made up of the same polymer electrode using glucose as a fuel.
The generated energy is
sufficient enough to operate an organic electrochemical
transistor type glucose sensor. The enzymatic fuel cell
could be utilise glucose to power other implantable electronic devices.
Currently,
the research team has developed the materials and demonstrated its operation
quantitatively and qualitatively. Further studies on device design,
biocompatibility and in-vivo characterizations may lead the technology towards
practical application.
(India Science Wire)
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